Serotonin 2A Receptors and Visual Hallucinations in Parkinson Disease
Identifieur interne : 001C83 ( Main/Exploration ); précédent : 001C82; suivant : 001C84Serotonin 2A Receptors and Visual Hallucinations in Parkinson Disease
Auteurs : Benedicte Ballanger [États-Unis] ; Antonio P. Strafella [États-Unis, Canada] ; Thilo Van Eimeren [États-Unis] ; Mateusz Zurowski [États-Unis] ; Pablo M. Rusjan [États-Unis] ; Sylvain Houle [États-Unis] ; Susan H. Fox [États-Unis]Source :
- Archives of neurology : (Chicago) [ 0003-9942 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Background: Complex visual hallucinations (VHs) occur in several pathologic conditions; however, the neural mechanisms underlying these symptoms remain unclear. Although dopamine may have a role, indirect evidence indicates that serotonin may also contribute to the pathogenesis of complex VHs, probably via involvement of the serotonin 2 receptor. Objective: To examine for the first time in vivo changes in serotonin 2A receptor neurotransmission among patients having Parkinson disease (PD) with VHs. Design: Case-control study. Setting: Academic research. Patients: Seven patients having PD with VHs and 7 age-matched patients having PD without VHs were recruited. Main Outcome Measures: We used the selective serotonin 2A receptor ligand setoperone F 18 during positron emission tomography among nondemented patients having PD with VHs. Results: Patients having PD with VHs demonstrate increased serotonin 2A receptor binding in the ventral visual pathway (including the bilateral inferooccipital gyrus, right fusiform gyrus, and inferotemporal cortex) as well as the bilateral dorsolateral prefrontal cortex, medial orbitofrontal cortex, and insula. Conclusions: This pilot study provides the first in vivo evidence suggesting a role for serotonin 2A receptors in mediating VHs via the ventral visual pathway in PD. Treatment studies should be performed using selective serotonin 2A receptor antagonists, which have important implications for the clinical management of VHs and psychosis in PD.
Affiliations:
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Rakoff PET Centre and Centre for Addiction and Mental Health, Toronto Western Hospital, and Division of Brain, Imaging and Behaviour-Systems Neuroscience</s1><s2>Toronto Western</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Toronto Western</wicri:noRegion></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M. Rakoff PET Centre and Centre for Addiction and Mental Health, Toronto Western Hospital, and Division of Brain, Imaging and Behaviour-Systems Neuroscience</s1><s2>Toronto Western</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Toronto Western</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Movement Disorders Centre, Toronto Western Hospital, and Division of Brain, Imaging and Behaviour-Systems Neuroscience</s1><s2>Toronto Western</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Toronto Western</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Research Institute , University Health Network, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M. Rakoff PET Centre and Centre for Addiction and Mental Health, Toronto Western Hospital, and Division of Brain, Imaging and Behaviour-Systems Neuroscience</s1><s2>Toronto Western</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Toronto Western</wicri:noRegion></affiliation></author><author><name sortKey="Zurowski, Mateusz" sort="Zurowski, Mateusz" uniqKey="Zurowski M" first="Mateusz" last="Zurowski">Mateusz Zurowski</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, Toronto Western Hospital, and Division of Brain, Imaging and Behaviour-Systems Neuroscience</s1><s2>Toronto Western</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Toronto Western</wicri:noRegion></affiliation></author><author><name sortKey="Rusjan, Pablo M" sort="Rusjan, Pablo M" uniqKey="Rusjan P" first="Pablo M." last="Rusjan">Pablo M. Rusjan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M. Rakoff PET Centre and Centre for Addiction and Mental Health, Toronto Western Hospital, and Division of Brain, Imaging and Behaviour-Systems Neuroscience</s1><s2>Toronto Western</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Toronto Western</wicri:noRegion></affiliation></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M. Rakoff PET Centre and Centre for Addiction and Mental Health, Toronto Western Hospital, and Division of Brain, Imaging and Behaviour-Systems Neuroscience</s1><s2>Toronto Western</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Toronto Western</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H." last="Fox">Susan H. Fox</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Movement Disorders Centre, Toronto Western Hospital, and Division of Brain, Imaging and Behaviour-Systems Neuroscience</s1><s2>Toronto Western</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Toronto Western</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term><term>Parkinson disease</term><term>Serotonine receptor</term><term>Visual hallucination</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Hallucination visuelle</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Récepteur sérotoninergique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Complex visual hallucinations (VHs) occur in several pathologic conditions; however, the neural mechanisms underlying these symptoms remain unclear. Although dopamine may have a role, indirect evidence indicates that serotonin may also contribute to the pathogenesis of complex VHs, probably via involvement of the serotonin 2 receptor. Objective: To examine for the first time in vivo changes in serotonin 2A receptor neurotransmission among patients having Parkinson disease (PD) with VHs. Design: Case-control study. Setting: Academic research. Patients: Seven patients having PD with VHs and 7 age-matched patients having PD without VHs were recruited. Main Outcome Measures: We used the selective serotonin 2A receptor ligand setoperone F 18 during positron emission tomography among nondemented patients having PD with VHs. Results: Patients having PD with VHs demonstrate increased serotonin 2A receptor binding in the ventral visual pathway (including the bilateral inferooccipital gyrus, right fusiform gyrus, and inferotemporal cortex) as well as the bilateral dorsolateral prefrontal cortex, medial orbitofrontal cortex, and insula. Conclusions: This pilot study provides the first in vivo evidence suggesting a role for serotonin 2A receptors in mediating VHs via the ventral visual pathway in PD. Treatment studies should be performed using selective serotonin 2A receptor antagonists, which have important implications for the clinical management of VHs and psychosis in PD.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name></noRegion><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H." last="Fox">Susan H. Fox</name><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><name sortKey="Rusjan, Pablo M" sort="Rusjan, Pablo M" uniqKey="Rusjan P" first="Pablo M." last="Rusjan">Pablo M. Rusjan</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name><name sortKey="Zurowski, Mateusz" sort="Zurowski, Mateusz" uniqKey="Zurowski M" first="Mateusz" last="Zurowski">Mateusz Zurowski</name></country><country name="Canada"><region name="Ontario"><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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